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It has been demonstrated that zinc concentrations are markedly decreased in prostate cancer cells [86], as well as inducing the reactivation of m-aconitase of the Kreb cycle

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Moreover, emerging research indicates that small intestinal epithelial cells (IECs), which play a critical role in nutrient digestion and absorption, undergo significant metabolic reprogramming in the context of CD

These include reduced microbial diversity, decreased abundance of beneficial taxa such as Bifidobacterium and Faecalibacterium prausnitzii , and increased representation of pro-inflammatory microbes (Khavandegar et al., 2024

However, these drugs still need further investigation of their safety and efficacy in more clinical studies

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